- 最后登录
- 2012-2-17
- 在线时间
- 79 小时
- 鲜花
- 19
- 注册时间
- 2008-9-9
- 阅读权限
- 100
- 精华
- 0
- 积分
- 487
- UID
- 9680
 
 - 威望
- 0
- 开心果
- 544
- 分享
- 0
- 帖子
- 272
|
Disentangling Genetic and Environmental Influences on Children’s Development:
Introducing A Novel Methodology
Gordon T. Harold, Katherine H. Shelton, Frances Rice, Jacky Boivin,
Dale Hay, Marianne Van Den, Bree Anita Thapar
Abstract: The present study describes a novel methodology to examine the interplay between genetic and
environmental influences on children’s development. Families of children aged 4 – 10 years born by one of five
methods of assisted reproductive technologies, specifically homologous in vitro fertilization (IVF), sperm
donation, egg donation, embryo donation, and gestational surrogacy, were contacted through fertility clinics and
mailed a set of questionnaires focusing on the quality of family interaction, parenting, marital satisfaction, parent
and child psychological health, economic conditions and family demographics. Analyses are described that
highlight the novelty of this research design to disentangle genetic, intrauterine and early social environmental
influences on children’s development. First, results are described whereby comparisons were made between
children born through assisted reproductive technologies and children conceived naturally in relation to patterns of
association between levels of interparental conflict, parent-to-child hostility and children’s symptoms of
depression. Second, results are described where comparisons were made between patterns of association between
parent depressive symptoms, family relationship quality (interparental and parent-child relations) and children’s
symptoms of depression. Finally, a strategy that allows examination of relative genetic and intrauterine
environmental influences on children’s health and mental health outcomes is described. Results are discussed in
relation to implications for development of future intervention and prevention programmes.
Keywords: assisted reproductive technologies; family relationships; gene × environment interaction |
|